Cov txheej txheem
1. Kev Lag Luam: Txoj Haujlwm Tseem Ceeb ntawm Polyvinyl Polypyrrolidone hauv kev ua lag luam tshuaj
2. Polyvinyl Polypyrrolidone: Cov yam ntxwv thiab cov txiaj ntsig
3. Daim ntawv thov ntawm polyvinyl polypyrrolidone hauv kev npaj ntawm cov tshuaj sib txawv
4. Kev tsom xam ntawm polyvinyl polypyrrolidone daim ntawv thov
5. Tam sim no cov xwm txheej thiab cov nyom ntawm kev lag luam kev lag luam
6. Yav Tom Ntej Kev Npaj thiab Txuj
1. Kev Lag Luam: Txoj Haujlwm Tseem Ceeb ntawm Polyvinyl Polypyrrolidone hauv kev ua lag luam tshuaj
Nyob rau hauv cov ntsiab lus ntawm lub booming kev lag luam hnub no, raws li kev lag luam kws tshuaj, raws li qhov tsis tseem ceeb ntawm kev npaj tshuaj, tau ua ib qho tseem ceeb ntxiv. Polyvinylprolidone (PVPP), raws li kev ua tau zoo nrog kev ua tau zoo, yog maj mam dhau los ua kev tsom xam ntawm cov tshuaj tshawb fawb thiab kev tsim khoom thiab kev tsim khoom thiab ntau lawm. Nrog nws lub cev nqaij daim tawv thiab tshuaj siv tseem ceeb, nws muab cov tshuaj tseem ceeb thiab ua rau muaj kev nyab xeeb thiab ua rau tus neeg mob cov tshuaj noj muaj qee yam. Los ntawm kev npaj ntawm qhov ncauj los txhaj tshuaj, los ntawm cov tshuaj tsoos dej rau cov tswj hwm tshiab, PVPP yog txhua qhov chaw txhim kho kev lag luam tshiab ntawm kev lag luam kws tshuaj.
2. Polyvinyl Polypyrrolidone: Cov yam ntxwv thiab cov txiaj ntsig
● Cov yam yooj yim
Polyvinyl Polypyrrolidoneyog dawb lossis ze li ntawm cov hmoov dawb nrog ib qho tsw me. Nws yog insoluble hauv dej, ethanol, ether thiab ib txwm organic cov kuab tshuaj, nrog lub suab nrov me me tshaj 300 degree. Nws yog cov hmoov hygroscopic thiab yooj yim-flowing hmoov nrog cov khoom muaj zog nthuav dav thiab nyuaj nrog ntau hom tshuaj.
● Cov yam ntxwv tshwj xeeb hauv cov tshuaj Fiel
Zoo ruaj khov:
PVPP tuaj yeem tsim cov khoom siv uas ruaj khov nrog cov tshuaj los ntawm huab cua ib puag ncig xws li huab cua, lub teeb, li lwm yam ntxiv rau lub txee txee ntawm cov tshuaj. Piv txwv li, hauv qee cov tshuaj uas rhiab rau oxidation, PVPP tuaj yeem txo qis kev sib cuag ntawm cov tshuaj thiab cov pa oxygen los ntawm kev pheej hmoo ntawm cov tshuaj oxidation thiab tsis zoo.
Zoo heev solubilization thiab dispersion:
Rau qee cov tshuaj tsis zoo, PVPP tuaj yeem siv cov pab pawg hydrophilic nyob rau hauv cov solubility los ua kom lub solubility los ua kom muaj kev daws teeb meem, li kev txhim kho cov tshuaj tsis muaj txiaj ntsig ntawm cov tshuaj. Cov yeeb yam no yog qhov tseem ceeb tshaj plaws hauv kev txhim kho cov tshuaj nqus cov tshuaj nqus.
Zoo heev zaj duab xis-ua cov cuab yeej:
PVPP tuaj yeem tsim cov khaub ncaws hnav thiab cov yeeb yaj kiab ntom ntom ntawm cov tshuaj, uas tuaj yeem cais tawm thiab tiv thaiv cov tshuaj. Nyob rau tib lub sijhawm, hauv qee cov ntaub ntawv Dosage, nws kuj tuaj yeem hloov kho cov tshuaj tso tawm kom ua tiav cov tshuaj.
3. Daim ntawv thov ntawm polyvinyl polypyrrolidone hauv kev npaj ntawm cov tshuaj sib txawv
Hmoov rau
1. Raws li kev ua txhaum: PVPP yog ib txwm siv tsis muaj kev ua tsis taus hauv ntsiav tshuaj. Thaum cov ntsiav tshuaj nkag mus rau hauv lub plab zom mov, PVPP yuav ua kom sai sai ntawm cov dej thiab swell, ua rau lub ntsiav tshuaj qauv tawg, yog li nrawm qhov tso tawm ntawm cov tshuaj. Piv txwv li, hauv cov ntsiav tshuaj sib cais, PvPP tuaj yeem ua kom cov ntsiav tshuaj ua kom sai sai nyob rau hauv lub plab, cia cov khoom xyaw kom sai li sai tau thaum ua tau kev ua tau zoo. Piv nrog rau lwm cov disintgravs, pvpp muaj cov nyhuv tseem ceeb thiab yuav tsis cuam tshuam rau qhov ruaj khov thiab saj ntawm cov tshuaj.
2. Txhim kho lub hardness thiab friability ntawm cov ntsiav tshuaj: muaj ntau npaum li cas ntawm cov ntsiav tshuaj tawg thiab xoob ntawm cov ntsiav tshuaj, kom muaj kev ncaj ncees ntawm cov ntsiav tshuaj thaum lub sijhawm cia thiab tsheb thauj mus los. Lub luag haujlwm ntawm PVPP tshwj xeeb yog ib qho tshwj xeeb yog nyob rau hauv kev tsim qee cov ntsiav tshuaj uas xav tau kev cia siab ntev lossis mus los ntawm kev sib txuas ntawm cov lus yooj yim.
● Cov tsiav tshuaj
1. Txhim kho cov tshuaj ruaj khov: rau qee cov tshuaj uas muaj kev tiv thaiv kom nqus tau zoo nyob rau hauv cov ntsiav tshuaj thiab tiv thaiv cov tshuaj los ntawm kev ua kom ntub dej vim yog ya raws. Nyob rau hauv kev npaj ntawm cov muag tsaj muag, PVPP tseem tuaj yeem ua tau zoo dua nrog cov tshuaj thiab lwm yam kev zam kom ntseeg tau tias qhov kev sib txawv ntawm cov capsules mos.
2. Txhawb tawm cov tshuaj tawm: Hauv cov ntsiav tshuaj enteric-coated, PVPP tuaj yeem pab rau hauv kev tso tawm hauv cov tshuaj tshwj xeeb ntawm cov hnyuv. Thaum cov ntsiav tshuaj ncav cuag txoj hnyuv, cov khoom o ntawm pvpp ua rau lub hau siav, cia cov tshuaj yuav tsum tau tawm hauv lub sijhawm, txhim kho kev nqus tau ntawm cov tshuaj hauv cov hnyuv. Nws yog qhov haum rau qee cov tshuaj uas yuav tsum tau ua haujlwm hauv txoj hnyuv, xws li tshuaj rau kev kho mob hnyuv.
● Kev Txhaj Tshuaj
1. Solubilization thiab stabilization: nyob rau hauv kev npaj ntawm kev txhaj tshuaj ntawm cov tshuaj muaj zog thiab tusyees dispersed thiab athibration hauv kev daws teeb meem, tsis txhob muaj nag lossis daus lossis stratification lossis stratification. Nyob rau tib lub sijhawm, nws kuj tseem tuaj yeem txhim kho qhov kev nyab xeeb ntawm kev txhaj tshuaj thiab tiv thaiv cov tshuaj los ntawm kev ua tsis zoo thaum lub sijhawm cia thiab siv. Piv txwv li, hauv qee cov kev txhaj tshuaj tiv thaiv mob qog, yuav tsum siv PVPP ua kom muaj kev nyab xeeb thiab kev nyab xeeb ntawm cov tshuaj.
2. Txo cov tshuaj nqus dej: PVPP muaj qee yam hydrophilicity thiab buffering cuam tshuam, uas tuaj yeem txo cov tshuaj rau ntawm qhov chaw txhaj tshuaj. Qee cov tshuaj uas ua rau cov hlab ntsha tuaj yeem txo cov mob ntshav thiab kev ua kom cov tshuaj tua neeg ua kev ua kom zoo tom qab ntxiv pvpp.
● TSHOOJ YEEM THIAB TXOJ KEV TSO CAI LOS NTAWM KEV TSO CAI
1. Hloov cov tshuaj tso tawm Yeeb Tshuaj: PVPP ua si lub luag haujlwm tseem ceeb hauv kev tswj hwm kev tso tawm thiab kev tso tawm tau npaj tseg. Los ntawm kev hloov pauv, particle loj thiab ua ke ntawm pvpp nrog rau lwm cov tshuaj siv tau kho tau raug kho kom tau raug kho kom tiav kom ua tiav cov tshuaj ntev thiab ruaj khov. Piv txwv li, hauv qee cov ntsiav tshuaj-tso tawm rau kev kho cov ntshav tawg thiab cov qauv kev ua kom txo cov tshuaj, txo cov tshuaj uas tus neeg mob tau siv tshuaj, thiab txhim kho cov kev kho mob.
2. Siv zog rau cov tshuaj uas tso tawm: Hauv kev tso tawm ntawm cov tshuaj, PVPP tuaj yeem nkag rau hauv lub cev los ntawm kev nkag mus rau hauv daim tawv nqaij thiab txuas ntxiv rau cov tshuaj lub sijhawm. Daim ntawv ntau npaum no tsis tsuas yog ua tau zoo ntawm cov tshuaj, tab sis kuj yuav txo cov kev mob tshwm sim los ntawm cov tshuaj, muab cov neeg mob yooj yim dua thiab nyiam noj cov tshuaj.
4. Kev tsom xam ntawm polyvinyl polypyrrolidone daim ntawv thov
1. Npaj ntawm ib qho kev paub zoo-paub txias tshuaj ntsiav tshuaj
Siv ib tug zoo tshaj plaws-muag compound kho tshuaj kho tshuaj ntsiav tshuaj ntawm kev ua lag luam ua piv txwv.{{0 {0}} pyrrolidone 1- yas vinyl polymeryog siv los ua kev ua txhaum nyob rau hauv cov txheej txheem npaj ntawm cov tshuaj no. Los ntawm nruj me ntsis kev tswj hwm cov tshuaj thiab particle loj ntawm PvPP, nws yog kom meej meej tawg tom qab nkag mus rau hauv lub plab thiab cov khoom muaj cov khoom muaj cov khoom muaj tso tawm sai sai. Cov chaw kuaj mob tau pom tias cov tshuaj kho mob khaub thuas siv PvPP ua ib qho kev tsis sib haum xeeb muaj lub sijhawm thiab cov neeg mob cov tsos mob tau txais txiaj ntsig sai dua. Nyob rau tib lub sijhawm, vim muaj kev cai zoo ntawm PvPP ntawm lub hardness thiab kev thauj khoom ntawm cov ntsiav tshuaj, thiab cov ntsiav tshuaj xoob, uas ua kom muaj kev sib tw zoo thiab kev ua lag luam zoo ntawm cov khoom lag luam.
2. Kev tshawb nrhiav thiab kev txhim kho ntawm kev txhaj tshuaj tiv thaiv mob
Thaum lub sijhawm tshawb nrhiav thiab kev txhim kho mob qog kev txhaj tshuaj, vim muaj kev tshawb fawb ruaj khov, kev tshawb nrhiav polyvyrorrolidone raws li cov cosvent thiab stabilization. Los ntawm kev txhim kho cov qauv thiab cov txheej txheem ntawm PvPP, cov tshuaj tau ua tiav zoo solubility thiab ruaj khov hauv kev txhaj tshuaj hnyav. Cov kev tshawb fawb soj ntsuam tau pom tias kev tiv thaiv mob qog kom tsis txhob muaj kev cuam tshuam rau cov tshuaj hauv lub cev, thiab cov tshuaj tiv thaiv kab mob tsis zoo. Txoj kev txhim kho zoo ntawm qhov kev txhaj tshuaj no muab kev kho mob ntxiv rau cov neeg mob cancer thiab tseem cuam tshuam cov ntawv thov tseem ceeb ntawm PVP.
5. Tam sim no cov xwm txheej thiab cov nyom ntawm kev lag luam kev lag luam
1. Tam sim no cov xwm txheej ntawm kev txhim kho kev lag luam
Tam sim no, lub ntiaj tebPoly (N-yas Pyrrolidone)Kev ua lag luam loj qhia qhov ruaj khov kev loj hlob sib txawv. Nrog kev txhim kho txuas ntxiv ntawm cov kev lag luam kws tshuaj, kev ua tau zoo thiab kev ua tau zoo thiab kev ua tau zoo rau kev siv tshuaj kom siab dua yog qhov siab dua thiab siab dua. Raws li ib qho kev ua tau zoo ua kom zoo, kev lag luam xav tau rau PVPP tseem nce ntxiv. Hauv Suav teb, vim tias cov kev tshawb fawb ntawm PVP (suav nrog PVPP) pib nyob rau hauv lub xyoo 1980s, kev lag luam tsim tau tiav, thiab daim ntawv thov tau ua tiav los ntawm ob peb lub chaw tshuaj tshuaj ntawm cov khoom siv tshuaj tiv thaiv cov khoom niaj hnub no. Ntau lub tuam txhab hauv tsev tau pib ua tib zoo mloog rau daim ntawv thov ntawm PvPP thiab txuas ntxiv kom nce cov peev txheej thiab kev tsim cov khoom lag luam.
2. Cov ntsej muag sib tw
Cov Qauv Zoo thiab Kev Saib Xyuas:
Txawm hais tias PVPP yog siv nyob rau hauv lub chaw tshuaj tshuaj, tseem muaj qee qhov tsis zoo tag nrho hauv cov qauv zoo thiab kev saib xyuas ntawm PvPP hauv Suav teb. Qhov zoo tshaj ntawm PVPP tsim los ntawm cov chaw tsim khoom sib txawv sib txawv, uas coj qee qhov nyuaj rau kev tswj cov tshuaj lag luam. Ntxiv dag zog rau cov qauv thiab kev saib xyuas ntawm PVPP cov qauv zoo kom ntseeg tau tias nws ua tau raws li cov cai ntawm qhov kev nyuaj siab tam sim no.
R & D thiab Tsim Kho Siab:
Nrog kev nce qib nro ntawm cov tshuaj thev naus laus zis ntawm cov ntaub ntawv siv tshuaj thiab cov tshuaj noj tshiab thiab siv tshuaj yeeb hauv cov tshuaj yog kev tawm mus tas li. PVPP xav tau txuas ntxiv mus nqa R & D thiab kev tsim kho kom haum rau cov kev pab tshiab no. Piv txwv li, hauv cov teb ntawm Nano Cov Khoom Siv Yeeb Tshuaj Siv tshuab thiab kev kho cov tshuaj muaj hom tshuaj, PVPP nrog cov khoom tshwj xeeb yuav tsum tau tsim kho. Txawm li cas los xij, cov peev txheej tam sim no R & D cov peev txheej tam sim no tseem tsawg, uas txwv tsis pub siv cov ntawv thov thiab kev txhim kho ntawm cov kev txiav ntawm cov kev txiav-ntug teb.
Khoom Raw Khoom Siv thiab Nqi:
Kev tsim cov PVPP yog nyob ntawm qee cov ntaub ntawv raw raw. Cov khoom ruaj khov thiab tus nqi hloov pauv ntawm cov khoom nyoos yuav cuam tshuam rau kev tsim khoom thiab kev lag luam ntawm PVPP. Nyob rau hauv xyoo tsis ntev los no, tus nqi ntawm ib co ntaub ntawv raw tau sawv rov los, uas tau cuam tshuam rau cov tuam txhab uas txaus siab siv thiab ua lag luam nce qib rau qee yam. Yuav ua li cas kom tau cov khoom siv raw thiab txo cov nqi tsim khoom kuj tseem muaj teeb meem uas kev lag luam yuav tsum daws.
6. Yav Tom Ntej Kev Npaj thiab Txuj
Kev ntsuas kev siv thev naus laus zis
1. Kev loj hlob ntawm cov khoom tshiab PvPP: yav tom ntej, nrog kev txhim kho cov khoom siv technology, peb yuav ua kom pom cov khoom lag luam pvpp tshiab nrog kev ua haujlwm zoo dua. Piv txwv li, tsim PVPP nrog cov neeg muaj tswv yim teb tau zoo tshaj plaws (xws li Ph, ntsuas kub thiab lwm yam); Los yog tsim cov papp ua ke nrog cov molecules bioactive los txhim kho cov phiaj xwm thiab kho cov yeeb yam.
2. Technology Tshuab Ntau Lawm Kev siv cov tshuaj lom neeg hluavtaws ntsuab rau kev txo cov khib nyiab thiab kev siv hluav taws xob hauv cov txheej txheem tsim khoom, txhim kho kev tsim kho cov txheej txheem ntau lawm, txhim kho kev loj hlob hauv pvpp ntau lawm tshuab hauv lub neej yav tom ntej.
● Kev ua lag luam Gaspection
Nrog rau kev siv zog ntawm kev laus ntawm cov pej xeem thoob ntiaj teb thiab kev txhim kho txuas ntxiv ntawm kev noj qab haus huv, kev ua lag luam yuav loj tuaj ntxiv. Raws li ib qho tseem ceeb kws tshuaj ntsuam, polyvinyl polypyrrolidone muaj kev lag luam kev lag luam dav. Nws cia siab tias lub lag luam PVPP thoob ntiaj teb yuav txuas ntxiv tswj hwm kev nyab xeeb nyob rau ob peb xyoos tom ntej no, tshwj xeeb tshaj yog nyob rau lub teb chaws uas tshwm sim. Nrog rau kev txhim kho sai sai ntawm cov kev lag luam kev lag luam thiab kev nce siab nce siab rau cov tshuaj zoo, kev lag luam sib koom ua ntej yuav tsum nthuav ntxiv. Nyob rau tib lub sijhawm, raws li daim ntawv thov ntawm PVPP hauv kev siv tshuaj tshiab cov tshuaj tshiab txuas ntxiv mus nthuav dav, nws cov kev xav tau lag luam yuav ua rau cov ntsiab lus loj hlob tshiab.
● Kev lag luam kev koom tes thiab kev loj hlob
Txhawm rau txhawb txoj kev txhim kho zoo ntawm covPolyvinyl PolypyrrolidoneKev lag luam, nws yog qhov tseem ceeb rau kev txhawb nqa kev sib koom tes hauv kev lag luam. Kws Tsim Khoom Siv Tuam Txhab, Kev Tshawb Fawb Kev Tshawb Fawb thiab Cov Thawj Coj Cov Cai yuav tsum muaj dua kev sib txuas lus thiab kev sib koom tes. Cov tuam txhab kws kho tshuaj tuaj yeem sib koom tes nrog cov chaw tshawb fawb los nqa R & D cov haujlwm, ua raws li kev nyuaj siab thiab tsim cov khoom lag luam tshiab; Cov cai tswj hwm yuav tsum ntxiv dag zog sib pauv nrog cov tuam txhab thiab kev tshawb fawb txog kev lag luam, thiab txhim kho cov qauv kev lag luam thiab kev tswj hwm cov cai. Tsis tas li ntawd, koom haum kev lag luam tuaj yeem ua tus choj thiab txuas txoj haujlwm sib pauv, kev kawm paub txog kev ua haujlwm thiab kev txhim kho ntawm tag nrho kev lag luam.
Hauv cov ntsiab lus, polyvinyl polypyrrolidone muaj cov ntawv thov dav thiab tseem ceeb hauv kev npaj tshuaj tshuaj nyob hauv cov chaw muag tshuaj.
Txawm hais tias qhov kev lag luam tam sim no ntsib qee qhov kev nyuaj siab, nrog kev txhim kho tshuab ua lag luam ua si hauv kev lag luam ntau ntxiv rau kev noj qab haus huv tom ntej thiab ua rau tib neeg kev noj qab haus huv. Peb tos ntsoov rau lub sijhawm kaj siab rau lub polyvinyl polypyrrolidone kev lag luam nrog kev sib koom tes ntawm txhua tog.